A light guide element and a method for manufacturing the same, and a lighting fixture are described. The light guide element includes a light guide body, a plurality of first and second microstructures corresponding to each other. The light guide body includes a first and a second light-emitting surface opposite to and parallel to each other. The first and second microstructures are respectively disposed on the first and second light-emitting surfaces by a first arrangement rule based on a first datum line and a second arrangement rule based on a second datum line. The first datum line is different from the second datum line. In a normal direction of the first light-emitting surface, each second microstructure laps over the corresponding first microstructure in part. When an incident light enters the light guide body, a first and a second mesh patterns are respectively formed on the first and second light-emitting surfaces.