Systems and methods for analyzing digital slide images. In an embodiment, a digital slide image is acquired from a specimen on a slide. Then, until it is determined that a quality of the digital slide image is sufficient, the quality of the digital slide image is determined and the digital slide image is reacquired. Once it is determined that the quality of the digital slide image is sufficient, the digital slide image and a measure of the quality of the digital slide image is provided to one or more recipients.