A computerized image guided biological cellular process progressive selection method receives at least one state cell image. A state cell region recognition is performed using the state cell image to generate state cell region output. A state cell measurement is performed using the state cell region to generate at least one state cell feature output. A state cell decision is performed using the state cell feature to generate state cell selection decision output. The selected cell is progressively selected in at least one follow-on states by its image guided state cell selection method. The method further includes at least one additional image acquired in a later frame of same state and state cell feature includes temporal features of growth patterns.