Methods, systems, and apparatus are provided for multiple-input multiple-output acoustic echo cancellation. A multiple-input multiple-output acoustic echo canceller (MIMO AEC) is provided as a high quality echo canceller for voice and/or audio communication over a network (e.g., packet switched network). The MIMO AEC is an extension of, as well as an application/usage of a single-input single-output acoustic echo canceller (“mono AEC”). The MIMO AEC is an extension of the mono AEC in that the code/theory underlying the mono AEC is adjusted for use with multiple channels. The manner in which AEC is applied (e.g., on each microphone signal using separate mono-AECs) is an application of mono-AECs.