Invention Grant
US09125384B2 Mouse having human leukemic stem cell and leukemic non-stem cell amplified therein, and method for production thereof
有权
具有扩增人白血病干细胞和白血病非干细胞的小鼠及其生产方法
- Patent Title: Mouse having human leukemic stem cell and leukemic non-stem cell amplified therein, and method for production thereof
- Patent Title (中): 具有扩增人白血病干细胞和白血病非干细胞的小鼠及其生产方法
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Application No.: US12738559Application Date: 2008-10-17
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Publication No.: US09125384B2Publication Date: 2015-09-08
- Inventor: Fumihiko Ishikawa , Yoriko Saito , Osamu Ohara , Leonard D. Shultz
- Applicant: Fumihiko Ishikawa , Yoriko Saito , Osamu Ohara , Leonard D. Shultz
- Applicant Address: JP Wako US ME Bar Harbor
- Assignee: RIKEN,The Jackson Laboratory
- Current Assignee: RIKEN,The Jackson Laboratory
- Current Assignee Address: JP Wako US ME Bar Harbor
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JP2007-271870 20071018
- International Application: PCT/JP2008/068892 WO 20081017
- International Announcement: WO2009/051238 WO 20090423
- Main IPC: A01K67/00
- IPC: A01K67/00 ; A01K67/027 ; A61K49/00 ; A61K39/395 ; G01N33/50 ; G01N33/569 ; G01N33/574
Abstract:
The invention relates to a method of selectively expanding human leukemic cells in a non-adult NOD/SCID/IL2rgnull mouse by transplanting a substance containing a leukemic stem cell derived from a human acute myelogenous leukemia patient to the mouse. In addition, the invention relates to screening for a medicament capable of eradicating leukemic stem cell (LSC), consideration of treatment methods suitable for individual patients, identification of a differentially expressed gene and the like, using a mouse with expanded human leukemic cells.
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