Invention Grant
- Patent Title: Humanized IL-6 and IL-6 receptor
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Application No.: US14490875Application Date: 2014-09-19
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Publication No.: US09125386B2Publication Date: 2015-09-08
- Inventor: Li-Hsien Wang , Anthony T. Dore, Jr. , Sean Stevens , Andrew J. Murphy
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee Address: US NY Tarrytown
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Agent Neil Miyamoto
- Main IPC: A01K67/027
- IPC: A01K67/027 ; C12N15/00 ; C07K14/54 ; C07K14/715
Abstract:
Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Rα locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.
Public/Granted literature
- US20150013022A1 HUMANIZED IL-6 AND IL-6 RECEPTOR Public/Granted day:2015-01-08
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