Invention Grant
- Patent Title: Devitalization and recellularization of cartilage
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Application No.: US11826523Application Date: 2007-07-16
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Publication No.: US09125743B2Publication Date: 2015-09-08
- Inventor: Silvia Sihui Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger , Mark Moore , Rony Thomas , Alyce Linthurst Jones
- Applicant: Silvia Sihui Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger , Mark Moore , Rony Thomas , Alyce Linthurst Jones
- Applicant Address: US VA Virginia Beach
- Assignee: LifeNet Health
- Current Assignee: LifeNet Health
- Current Assignee Address: US VA Virginia Beach
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: A61F2/02
- IPC: A61F2/02 ; A61F2/30 ; A61F2/28 ; A61F2/46 ; A61L27/38 ; A61L27/36 ; A61F2/38

Abstract:
The present invention is directed toward recellularizing a devitalized cartilage graft with viable recellularizable cells in vivo, in situ, or in vitro to render the tissue vital. The present invention is also directed toward repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, recellularizing the devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally stored between the removing cellular debris and the recellularizing steps. The present invention is directed to both recellularized cartilage grafts as well as a process for recellularizing cartilage grafts.
Public/Granted literature
- US20090024229A1 Devitalization and recellularization of cartilage Public/Granted day:2009-01-22
Information query
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