Invention Grant
- Patent Title: Nanodrug targeting protein geranylgeranylation
- Patent Title (中): 香草酰胆碱甲酰化作用
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Application No.: US14447176Application Date: 2014-07-30
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Publication No.: US09125821B2Publication Date: 2015-09-08
- Inventor: Fuyuhiko Tamanoi , Jie Lu , Kohei Yoshimura , Ohyun Kwon , Hannah Fiji , Masaru Watanabe
- Applicant: The Regents of the University of California , NOF CORPORATION
- Applicant Address: US CA Oakland JP Tokyo
- Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,NOF CORPORATION
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,NOF CORPORATION
- Current Assignee Address: US CA Oakland JP Tokyo
- Agency: Venable, LLP
- Agent Keith G. Haddaway; Nancy J. Axelrod
- Main IPC: C07D207/48
- IPC: C07D207/48 ; C07D213/89 ; A61K31/402 ; A61K31/4418 ; A61K9/127 ; A61K31/40 ; A61K45/06 ; C07D207/20 ; C07D211/96 ; A61K31/216
Abstract:
The present invention relates, for example, to a liposome, which can be a basic liposome, a transferrin-conjugated liposome, or a pH-sensitive liposome, which encapsulates a compound that specifically inhibits the activity of a protein prenyltransferase, such as a RabGGTase and/or a GGTase I. The liposomes can be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.
Public/Granted literature
- US20140341979A1 NANODRUG TARGETING PROTEIN GERANYLGERANYLATION Public/Granted day:2014-11-20
Information query
