Methods and systems for processing organic trans-resveratrol for use in dietary supplements is disclosed. The process begins with harvesting grapes, stems and leaves, placing them in a cloth sack and delivering the grapes, stems and leaves to a nearby processing facility within less than 25 minutes. Thereafter, grapes are pressed to extract the juice and the residual pomace of skin, seeds and stems is removed from the pressing cylinder, ground to a fine mesh powder (approximately 50 mesh size), mixed with a bioflavanoid compound and polygonum cuspidatum, handled in controlled temperatures between approximately 10.0° C. (50 degrees F.) to approximately 30° C. (86 degrees F.) and with humidity of the storage area at less than 35%. The process results in a high quality and high quantity yield of a stable, organic trans-resveratrol for use in dietary supplements that are bioavailable and easily absorbed by the consumer of the dietary supplement.