Invention Grant
- Patent Title: Synergistic combinations to reduce particle dose for targeted treatment of cancer and its metastases
- Patent Title (中): 协同组合减少靶向治疗癌症及其转移的粒子剂量
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Application No.: US13296203Application Date: 2011-11-14
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Publication No.: US09125835B2Publication Date: 2015-09-08
- Inventor: Patrick J. Sinko , Jieming Gao , Manjeet Deshmukh , Xiaoping Zhang , Matthew S. Palombo , Sherif Ibrahim
- Applicant: Patrick J. Sinko , Jieming Gao , Manjeet Deshmukh , Xiaoping Zhang , Matthew S. Palombo , Sherif Ibrahim
- Applicant Address: US NJ New Brunswick
- Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- Current Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- Current Assignee Address: US NJ New Brunswick
- Agency: Fox Rothschild LLP
- Main IPC: A61K31/385
- IPC: A61K31/385 ; A61K9/51 ; A61K31/337 ; A61K31/4745 ; A61K31/65 ; B82Y5/00 ; A61K45/06 ; A61K31/519 ; A61K31/555 ; A61K31/675 ; A61K31/704 ; C08G65/329
Abstract:
Non-Small Cell Lung Carcinomas (NSCLCs) are treated with Gel Micro-Particles (GMPs) that passively accumulate in the lungs and contain Nano-Particles (NPs) combining one or more therapeutic agents that are cytotoxic to the NSCLC with one or more NSCLC active targeting ligands, as well as one or more other optional agents that increase cellular uptake, enhance the pro-apoptotic effect of the chemotherapeutic agent(s), and the like. NPs targeting other cancer cells are also disclosed, as well as NP-containing GMPs that reduce the occurrence of tumor metastasis.
Public/Granted literature
- US20120183621A1 SYNERGISTIC COMBINATIONS TO REDUCE PARTICLE DOSE FOR TARGETED TREATMENT OF CANCER AND ITS METASTASES Public/Granted day:2012-07-19
Information query
