Invention Grant
- Patent Title: Use of the cathelicidin LL-37 and derivatives thereof for wound healing
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Application No.: US14567267Application Date: 2014-12-11
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Publication No.: US09125875B2Publication Date: 2015-09-08
- Inventor: Mona Ståhle-Bäckdahl , Johan Heilborn , Anders Carlsson , Conny Bogentoft
- Applicant: Lipopeptide AB
- Applicant Address: SE Stockholm
- Assignee: Lipopeptide AB
- Current Assignee: Lipopeptide AB
- Current Assignee Address: SE Stockholm
- Agency: McCarter & English, LLP
- Agent Steven G. Davis
- Priority: SE0300207 20030129
- Main IPC: A61K38/17
- IPC: A61K38/17 ; A61K9/127 ; A61K38/16 ; C07K14/47 ; C12N5/00 ; C12N5/071

Abstract:
Use of the antimicrobial cathelicidin peptide II-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithelial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37.
Public/Granted literature
- US20150094256A1 USE OF THE CATHELICIDIN LL-37 AND DERIVATIVES THEREOF FOR WOUND HEALING Public/Granted day:2015-04-02
Information query
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