中科微点-全球专利检索

  1. Login
  2. Sign Up
Invention Grant
US09125877B2 Use of kauranes compounds in the manufacture of medicament 有权
木兰糖苷化合物在制备药物中的应用

  • Patent Title: Use of kauranes compounds in the manufacture of medicament
  • Patent Title (中): 木兰糖苷化合物在制备药物中的应用
  • Application No.: US11596514
    Application Date: 2004-05-19
  • Publication No.: US09125877B2
    Publication Date: 2015-09-08
  • Inventor: Wen Tan
  • Applicant: Wen Tan
  • Agency: Osha Liang LLP
  • International Application: PCT/CN2004/000508 WO 20040519
  • International Announcement: WO2005/110383 WO 20051124
  • Main IPC: A61K31/19
  • IPC: A61K31/19 ;  A61K31/191 ;  A61K31/045 ;  A61K31/047
Use of kauranes compounds in the manufacture of medicament
Abstract:
The invention relates the pharmaceutical use of kaurene compounds of formula (1) in treating and preventing coronary disease, stroke, cerebral ischemia and arrhythmia etc. The said compounds also have significant protecting effects against cerebral ischemic infarction. Wherein R1: hydrogen, hydroxyl or alkoxy R2: carboxyl, carboxylate, acyl halides, aldehyde, methylhydroxyl, and ester, acylamide, acyl or ether group hydrolysable to carboxyl. R3, R4, R5, R6, R8: independently, oxygen, hydroxyl, methylhydroxyl, and ester or alkyloxymethyl group hydrolysable to methylhydroxyl, R7: methyl, hydroxyl, and ester or alkyloxymethyl hydrolysable to methylhydroxyl, R9: methylene or oxygen.
Abstract(Chinese):

本发明涉及式（1）的凯仑酮化合物在治疗和预防冠状动脉疾病，中风，脑缺血和心律失常等方面的药物用途。所述化合物还具有对脑缺血梗死的显着保护作用。 其中R1：氢，羟基或烷氧基R2：羧基，羧酸酯，酰基卤，醛，甲基羟基和酯，酰基酰胺，可水解成羧基的酰基或醚基。 R 3，R 4，R 5，R 6，R 8：独立地是氧，羟基，甲基羟基和可水解成甲基羟基的酯或烷氧基甲基，R7：甲基，羟基和可水解成甲基羟基的酯或烷氧基甲基，R9：亚甲基或氧。

Public/Granted literature
Information query
Espacenet
Patent Agency Ranking
0/0