Invention Grant
US09125883B2 Sulfated depolymerized derivatives of exopolysaccharides (EPS) from mesophilic marine bacteria, method for preparing same, and uses thereof in tissue regeneration
有权
来自嗜温海洋细菌的外多糖（EPS）的硫酸化解聚衍生物，其制备方法及其在组织再生中的应用
- Patent Title: Sulfated depolymerized derivatives of exopolysaccharides (EPS) from mesophilic marine bacteria, method for preparing same, and uses thereof in tissue regeneration
- Patent Title (中): 来自嗜温海洋细菌的外多糖（EPS）的硫酸化解聚衍生物，其制备方法及其在组织再生中的应用
-
Application No.: US14052133Application Date: 2013-10-11
-
Publication No.: US09125883B2Publication Date: 2015-09-08
- Inventor: Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
- Applicant: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER) , UNIVERSITE RENE DESCARTES PARIS 5
- Applicant Address: FR Issy les Moulineaux FR Paris
- Assignee: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER),UNIVERSITE RENE DESCARTES PARIS 5
- Current Assignee: INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER (IFREMER),UNIVERSITE RENE DESCARTES PARIS 5
- Current Assignee Address: FR Issy les Moulineaux FR Paris
- Agency: Marshall, Gerstein & Borun LLP
- Priority: FR0406405 20040614
- Main IPC: A61K31/737
- IPC: A61K31/737 ; C12N5/0775 ; A61K35/28 ; C08B37/00
Abstract:
The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerization of said native EPSs followed by a step of sulphating the resulting depolymerized derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg (m) g/ml.
Public/Granted literature
Information query
IPC分类:
