Invention Grant
US09125945B2 Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
有权
含氯吡格雷和磺烷基醚环糊精的制剂及其使用方法
- Patent Title: Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
- Patent Title (中): 含氯吡格雷和磺烷基醚环糊精的制剂及其使用方法
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Application No.: US14507693Application Date: 2014-10-06
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Publication No.: US09125945B2Publication Date: 2015-09-08
- Inventor: Gerold L. Mosher , Rebecca L. Wedel , Karen T. Johnson , Stephen G. Machatha , Jane A. Cowee , Daniel J. Cushing
- Applicant: Cydex Pharmaceuticals, Inc.
- Applicant Address: US KS Lenexa
- Assignee: Cydex Pharmaceuticals, Inc.
- Current Assignee: Cydex Pharmaceuticals, Inc.
- Current Assignee Address: US KS Lenexa
- Agency: Knobbe Martens Olson & Bear LLP
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K47/40 ; A61K9/00 ; A61K9/08 ; A61K9/19 ; A61K31/4365 ; A61K31/724 ; A61K31/727 ; A61K45/06 ; A61K47/48 ; B82Y5/00

Abstract:
The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and/or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD.
Public/Granted literature
- US20150025243A1 FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYL ETHER CYCLODEXTRIN AND METHODS OF USE Public/Granted day:2015-01-22
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