Invention Grant
US09125947B2 Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, method of making and use thereof
有权
苯基乙酸，苯基丙酸和苯基丙酸共轭物和氢可酮的前体药物，其制备方法和用途
- Patent Title: Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, method of making and use thereof
- Patent Title (中): 苯基乙酸，苯基丙酸和苯基丙酸共轭物和氢可酮的前体药物，其制备方法和用途
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Application No.: US14493611Application Date: 2014-09-23
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Publication No.: US09125947B2Publication Date: 2015-09-08
- Inventor: Travis Mickle , Sven Guenther , Christal Mickle
- Applicant: KemPharm, Inc.
- Applicant Address: US IA Coralville
- Assignee: KemPharm, Inc.
- Current Assignee: KemPharm, Inc.
- Current Assignee Address: US IA Coralville
- Agency: McAndrews, Held & Malloy, Ltd.
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/19 ; A61K47/48 ; A61K31/485
Abstract:
The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
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