Invention Grant
US09125951B2 Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
有权
用于制备金黄色葡萄球菌血清型5和8的荚膜多糖缀合物免疫原性组合物的组合物和方法
- Patent Title: Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
- Patent Title (中): 用于制备金黄色葡萄球菌血清型5和8的荚膜多糖缀合物免疫原性组合物的组合物和方法
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Application No.: US13379291Application Date: 2010-06-22
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Publication No.: US09125951B2Publication Date: 2015-09-08
- Inventor: Stephen John Freese , Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Tracy Dee Scott , Jasdeep Singh Nanra , A. Krishna Prasad , Bruce Arthur Green
- Applicant: Stephen John Freese , Annaliesa Anderson , Viliam Pavliak , Kathrin Ute Jansen , Ingrid Lea Scully , Tracy Dee Scott , Jasdeep Singh Nanra , A. Krishna Prasad , Bruce Arthur Green
- Applicant Address: US NY New York
- Assignee: Wyeth LLC
- Current Assignee: Wyeth LLC
- Current Assignee Address: US NY New York
- Agent Victoria S. Molenda
- International Application: PCT/US2010/039473 WO 20100622
- International Announcement: WO2011/041003 WO 20110407
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/085 ; A61K39/385 ; A61K47/48
Abstract:
The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).
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