Systems and methods for an Automated Document Factory (ADF) system configured to print a web in a 4-up format and to handle the web with 2-up post-print equipment. One embodiment is an apparatus that includes a post-print system. The post-print system receives a web of media printed in an N-up format where N is three or more. The post-print system includes a cutting unit that cuts the web along a length to form segments. A first segment includes documents printed in a 2-up format. The post-print system also includes a 2-up handler that receives the first segment, reads an instruction printed on the first segment that includes handling information for the documents printed on the first segment, and processes the documents printed on the first segment based on the handling information.