A remote actuation system for de-manning a human/machine interface emulates the interface protocol to interact with the interface at a mechanical level. The system may function autonomously or with a remote human operator. At least one imaging module and at least one switch module with the same relative positions as and a complementary relief to the interface's gauge(s) and mechanical switch(es) are mounted on the instrument panel. The modules may be individually mounted or provided on a remote actuation panel that fits over the instrument panel. A data cable connects the imaging and switch modules to a processing module having at least one computer processor configured to execute an image-processing sub-module and a switch sub-module to emulate the protocol to interact with the interface at a mechanical level. The estimate of the measured value may be fed back to generate the switch command to control the remote switch actuator.