Invention Grant
US09126928B2 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I and preparation method therefor
有权
4-羟基-2-氧代-1-吡咯烷乙酰胺外消旋体晶形I及其制备方法
- Patent Title: 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I and preparation method therefor
- Patent Title (中): 4-羟基-2-氧代-1-吡咯烷乙酰胺外消旋体晶形I及其制备方法
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Application No.: US14237893Application Date: 2012-04-24
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Publication No.: US09126928B2Publication Date: 2015-09-08
- Inventor: Lei Ye
- Applicant: Lei Ye
- Applicant Address: CN Chongqing
- Assignee: Chongqing Runze Pharmaceutical Co., Ltd.
- Current Assignee: Chongqing Runze Pharmaceutical Co., Ltd.
- Current Assignee Address: CN Chongqing
- Agent Leong C. Lei
- Priority: CN201110230079 20110811
- International Application: PCT/CN2012/074573 WO 20120424
- International Announcement: WO2013/020390 WO 20130214
- Main IPC: C07D207/273
- IPC: C07D207/273

Abstract:
Disclosed is a 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I which is prepared by the following steps: dissolving crude 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate in a solvent such as a micromolecular alcohol to form a saturated solution; heating and stirring the solution overnight at 38˜42° C. to obtain a suspended precipitate; filtering and drying the solution to obtain a crystal. Such 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has a purity as high as 99.5%, which has significant treatment effect on curing respective diseases, and the 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has the features of simple manufacturing method, mild control condition, and low production cost, and its yield rate is as high as 99.5% which is applicable for mass production.
Public/Granted literature
- US20140221670A1 4-HYDROXY-2-OXO-1-PYRROLIDINEACETAMIDE RACEMATE CRYSTAL FORM I AND PREPARATION METHOD THEREFOR Public/Granted day:2014-08-07
Information query
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