Invention Grant
US09126928B2 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I and preparation method therefor 有权
4-羟基-2-氧代-1-吡咯烷乙酰胺外消旋体晶形I及其制备方法

  • Patent Title: 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I and preparation method therefor
  • Patent Title (中): 4-羟基-2-氧代-1-吡咯烷乙酰胺外消旋体晶形I及其制备方法
  • Application No.: US14237893
    Application Date: 2012-04-24
  • Publication No.: US09126928B2
    Publication Date: 2015-09-08
  • Inventor: Lei Ye
  • Applicant: Lei Ye
  • Applicant Address: CN Chongqing
  • Assignee: Chongqing Runze Pharmaceutical Co., Ltd.
  • Current Assignee: Chongqing Runze Pharmaceutical Co., Ltd.
  • Current Assignee Address: CN Chongqing
  • Agent Leong C. Lei
  • Priority: CN201110230079 20110811
  • International Application: PCT/CN2012/074573 WO 20120424
  • International Announcement: WO2013/020390 WO 20130214
  • Main IPC: C07D207/273
  • IPC: C07D207/273
4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I and preparation method therefor
Abstract:
Disclosed is a 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I which is prepared by the following steps: dissolving crude 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate in a solvent such as a micromolecular alcohol to form a saturated solution; heating and stirring the solution overnight at 38˜42° C. to obtain a suspended precipitate; filtering and drying the solution to obtain a crystal. Such 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has a purity as high as 99.5%, which has significant treatment effect on curing respective diseases, and the 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has the features of simple manufacturing method, mild control condition, and low production cost, and its yield rate is as high as 99.5% which is applicable for mass production.
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