Invention Grant
US09126932B2 Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
有权
取代的1,2,3,4-四氢环戊二烯并[b]吲哚-3-基）乙酸衍生物，用于治疗自身免疫性和炎性疾病
![Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders](/docs/US/2015-09-08/US09126932B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
- Patent Title (中): 取代的1,2,3,4-四氢环戊二烯并[b]吲哚-3-基）乙酸衍生物，用于治疗自身免疫性和炎性疾病
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Application No.: US14048768Application Date: 2013-10-08
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Publication No.: US09126932B2Publication Date: 2015-09-08
- Inventor: Robert M. Jones , Daniel J. Buzard , Sangdon Han , Sun Hee Kim , Juerg Lehmann , Brett Ullman , Jeanne V. Moody , Xiuwen Zhu , Scott Stim
- Applicant: Arena Pharmaceuticals, Inc.
- Applicant Address: US CA San Diego
- Assignee: Arena Pharmaceuticals, Inc.
- Current Assignee: Arena Pharmaceuticals, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Fish & Richardson P.C.
- Agent Lyle W. Spruce
- Main IPC: C07D209/94
- IPC: C07D209/94 ; C07D209/70 ; C07D209/88 ; C07D401/12 ; C07D403/12 ; C07D417/12 ; C07C211/27 ; C07C229/26 ; C07C255/03 ; C07C279/14
![Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders](/abs-image/US/2015/09/08/US09126932B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.
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