Invention Grant
US09126946B2 Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
有权
可用于制备1- [3-（4-溴-2-甲基-2H-吡唑-3-基）-4-甲氧基 - 苯基] -3-（2,4-二氟 - 苯基）脲和结晶 与之相关的形式
![Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto](/docs/US/2015-09-08/US09126946B2/abs.jpg.600x600.jpg)
- Patent Title: Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
- Patent Title (中): 可用于制备1- [3-（4-溴-2-甲基-2H-吡唑-3-基）-4-甲氧基 - 苯基] -3-（2,4-二氟 - 苯基）脲和结晶 与之相关的形式
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Application No.: US13126563Application Date: 2009-10-27
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Publication No.: US09126946B2Publication Date: 2015-09-08
- Inventor: Marlon Carlos , Weitong Dong , Mark Macias , Suzanne Michiko Sato , Lee Alani Selvey
- Applicant: Marlon Carlos , Weitong Dong , Mark Macias , Suzanne Michiko Sato , Lee Alani Selvey
- Applicant Address: US CA San Diego
- Assignee: Arena Pharmaceuticals, Inc.
- Current Assignee: Arena Pharmaceuticals, Inc.
- Current Assignee Address: US CA San Diego
- International Application: PCT/US2009/005809 WO 20091027
- International Announcement: WO2010/062321 WO 20100603
- Main IPC: A61K31/415
- IPC: A61K31/415 ; C07C231/16 ; C07D231/16
![Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto](/abs-image/US/2015/09/08/US09126946B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is directed to processes and intermediates useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea (Compound I), crystalline forms and solvate forms thereof; and compositions comprising 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea, crystalline forms and solvate forms thereof prepared by processes as described herein.
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