Invention Grant
- Patent Title: Hydroxy group protecting agent and hydroxy group protection method
- Patent Title (中): 羟基保护剂和羟基保护方法
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Application No.: US14359183Application Date: 2012-11-16
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Publication No.: US09126954B2Publication Date: 2015-09-08
- Inventor: Munetaka Kunishima , Hikaru Fujita , Kohei Yamada
- Applicant: Munetaka Kunishima , Hikaru Fujita , Kohei Yamada
- Applicant Address: JP Kanazawa-shi, Ishikawa
- Assignee: NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY
- Current Assignee: NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY
- Current Assignee Address: JP Kanazawa-shi, Ishikawa
- Agent Manabu Kanesaka
- Priority: JP2011-253002 20111118
- International Application: PCT/JP2012/079834 WO 20121116
- International Announcement: WO2013/073681 WO 20130523
- Main IPC: C07D251/34
- IPC: C07D251/34 ; C07D251/30 ; C07C41/14 ; C07B51/00 ; C07C67/24 ; C07C67/29 ; C07C67/62 ; C07D251/26

Abstract:
To provide: a hydroxy group protecting agent which is stable and easy to use, does not have carcinogenicity, a tearing property or the like, and is inexpensive; and a hydroxy group protection method which enables the protection of a hydroxy group under acidic conditions.[Solution] A hydroxy group protecting agent in which at least one protecting group is bound to a nitrogen-containing electron-withdrawing heterocyclic ring through any one of an oxygen atom, a sulfur atom and a nitrogen atom. The heterocyclic ring is a triazine ring or the like, and the protecting group is a benzyl group or the like. Specifically, the hydroxy group protecting agent is 2,4,6-tribenzyloxy-1,3,5-triazine, 2,4,6-tris(4-methoxybenzyloxy)-1,3,5-triazine or the like. In addition, 2,4,6-tris(t-butoxy)-1,3,5-triazine or the like can also be used. For protecting a hydroxy group, a compound of interest which has a hydroxy group is reacted with the hydroxy group protecting agent under acidic conditions.
Public/Granted literature
- US20140343281A1 HYDROXY GROUP PROTECTING AGENT AND HYDROXY GROUP PROTECTION METHOD Public/Granted day:2014-11-20
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