Invention Grant
- Patent Title: Selective glycosidase inhibitors and uses thereof
- Patent Title (中): 选择性糖苷酶抑制剂及其用途
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Application No.: US14238481Application Date: 2012-08-10
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Publication No.: US09126957B2Publication Date: 2015-09-08
- Inventor: Harold G. Selnick , Kun Liu , Ernest J. McEachern , Yuanxi Zhou , Yongbao Zhu
- Applicant: Harold G. Selnick , Kun Liu , Ernest J. McEachern , Yuanxi Zhou , Yongbao Zhu
- Applicant Address: US NJ Rahway CA Burnaby, British Columbia
- Assignee: MERCK SHARP & DOHME CORP.,ALECTOS THERAPEUTICS, INC.
- Current Assignee: MERCK SHARP & DOHME CORP.,ALECTOS THERAPEUTICS, INC.
- Current Assignee Address: US NJ Rahway CA Burnaby, British Columbia
- Agent J. Eric Thies; John C. Todaro
- International Application: PCT/US2012/050225 WO 20120810
- International Announcement: WO2013/025452 WO 20130221
- Main IPC: A61K31/423
- IPC: A61K31/423 ; A61K31/428 ; C07D263/58 ; C07D413/04 ; C07D417/04 ; C07D277/60 ; C07D277/82
Abstract:
The invention is directed to compounds for selectively inhibiting glycosidases, uses of the compounds and pharmaceutical compositions including the compounds, and methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, and/or accumulation or deficiency of O-GlcNAc.
Public/Granted literature
- US20140206665A1 SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2014-07-24
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