Invention Grant
- Patent Title: Ribonucleotide reductase inhibitors and methods of use
- Patent Title (中): 核糖核苷酸还原酶抑制剂及其使用方法
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Application No.: US14444172Application Date: 2014-07-28
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Publication No.: US09126960B2Publication Date: 2015-09-08
- Inventor: David Horne , Christopher Lincoln
- Applicant: City of Hope
- Applicant Address: US CA Duarte
- Assignee: City of Hope
- Current Assignee: City of Hope
- Current Assignee Address: US CA Duarte
- Agency: Mintz, Levin, Cohen, Ferris, Glovsky and Popeo, P.C.
- Main IPC: C07D277/46
- IPC: C07D277/46 ; C07D277/40 ; C07C45/68
Abstract:
Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
Public/Granted literature
- US20150087844A1 RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE Public/Granted day:2015-03-26
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