Invention Grant
- Patent Title: Fluorination process
- Patent Title (中): 氟化工艺
-
Application No.: US13848877Application Date: 2013-03-22
-
Publication No.: US09126961B2Publication Date: 2015-09-08
- Inventor: Anthony Eamon Storey , Clare Louise Jones , Denis Raymond Christophe Bouvet , Nicholas Lasbistes , Steven Michael Fairway , Lorenzo Williams , Alexander Mark Gibson , Robert James Nairne , Farhad Karimi , Bengt Langstrom
- Applicant: GE HEALTHCARE LIMITED , GE HEALTHCARE AS
- Applicant Address: GB Buckinghamshire NO Oslo
- Assignee: GE Healthcare Limited,GE Healthcare AS
- Current Assignee: GE Healthcare Limited,GE Healthcare AS
- Current Assignee Address: GB Buckinghamshire NO Oslo
- Agency: Parks Wood LLC
- Agent Collen A. Beard, Esq.
- Priority: GB0516564.2 20130322
- Main IPC: C07D277/66
- IPC: C07D277/66
Abstract:
The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
Public/Granted literature
- US20130225829A1 FLUORINATION PROCESS Public/Granted day:2013-08-29
Information query
