Invention Grant
- Patent Title: Process for the preparation of statins in the presence of base
- Patent Title (中): 在基础存在下制备他汀类药物的方法
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Application No.: US13979976Application Date: 2012-01-13
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Publication No.: US09126975B2Publication Date: 2015-09-08
- Inventor: Karin Henderika Maria Bessembinder , Dennis Heemskerk , Ben De Lange
- Applicant: Karin Henderika Maria Bessembinder , Dennis Heemskerk , Ben De Lange
- Applicant Address: NL Delft
- Assignee: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.
- Current Assignee: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.
- Current Assignee Address: NL Delft
- Agency: Nixon & Vanderhye P.C.
- Priority: EP11151280 20110118; EP11184685 20111011
- International Application: PCT/EP2012/050470 WO 20120113
- International Announcement: WO2012/098049 WO 20120726
- Main IPC: C07D405/06
- IPC: C07D405/06 ; C07D413/12 ; C07D419/12
Abstract:
The present invention relates to a process for the preparation of statins by means of a Julia-Kocienski reaction between an aldehyde and a sulfone derivative in the presence of an alkaline metal alkoxy base. The resulting derivatives are suitable as building blocks for statin type compounds such as cerivastatin, fluvastatin, pitavastatin and rosuvastatin.
Public/Granted literature
- US20130296561A1 PROCESS FOR THE PREPARATION OF STATINS IN THE PRESENCE OF BASE Public/Granted day:2013-11-07
Information query
