Invention Grant
US09126990B2 Method for synthesizing rivaroxaban intermediate, 4-(4-[(5S)-(aminomethyl)-2-oxo-1,3-oxazoligdin-3-YL]phenyl)morpholin-3-one
有权
合成利伐沙班中间体4-（4 - [（5S） - （氨基甲基）-2-氧代-1,3-恶唑啶-3-基]苯基）吗啉-3-酮的方法
![Method for synthesizing rivaroxaban intermediate, 4-(4-[(5S)-(aminomethyl)-2-oxo-1,3-oxazoligdin-3-YL]phenyl)morpholin-3-one](/docs/US/2015-09-08/US09126990B2/abs.jpg.600x600.jpg)
- Patent Title: Method for synthesizing rivaroxaban intermediate, 4-(4-[(5S)-(aminomethyl)-2-oxo-1,3-oxazoligdin-3-YL]phenyl)morpholin-3-one
- Patent Title (中): 合成利伐沙班中间体4-（4 - [（5S） - （氨基甲基）-2-氧代-1,3-恶唑啶-3-基]苯基）吗啉-3-酮的方法
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Application No.: US14126361Application Date: 2012-01-18
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Publication No.: US09126990B2Publication Date: 2015-09-08
- Inventor: Chunpeng Zi , Luning Huang , Jeannie Zhang
- Applicant: Chunpeng Zi , Luning Huang , Jeannie Zhang
- Applicant Address: CN Zhejiang CN Shanghai
- Assignee: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD,SHANGHAI SYNCORES TECHNOLOGIES, INC.
- Current Assignee: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD,SHANGHAI SYNCORES TECHNOLOGIES, INC.
- Current Assignee Address: CN Zhejiang CN Shanghai
- Agency: Norton Rose Fulbright US LLP
- Priority: CN201110158823 20110614
- International Application: PCT/CN2012/070530 WO 20120118
- International Announcement: WO2012/171343 WO 20121220
- Main IPC: C07D413/10
- IPC: C07D413/10
![Method for synthesizing rivaroxaban intermediate, 4-(4-[(5S)-(aminomethyl)-2-oxo-1,3-oxazoligdin-3-YL]phenyl)morpholin-3-one](/abs-image/US/2015/09/08/US09126990B2/abs.jpg.150x150.jpg)
Abstract:
The present invention discloses novel methods for synthesizing Rivaroxaban intermediate, i.e., 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one. The novel methods provided in the present invention involve mild reaction conditions, convenient operations, easy purification, and low production costs, and thus the process is environmental-friendly and suitable for industrial production.
Public/Granted literature
- US20140114066A1 NOVEL METHOD FOR SYNTHESIZING RIVAROXABAN INTERMEDIATE, 4-MORPHOLIN-3-ONE Public/Granted day:2014-04-24
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