Invention Grant
- Patent Title: Crystalline form of a quinolinone-carboxamide compound
- Patent Title (中): 喹啉酮 - 甲酰胺化合物的结晶形式
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Application No.: US14150059Application Date: 2014-01-08
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Publication No.: US09126994B2Publication Date: 2015-09-08
- Inventor: Paul R. Fatheree , S. Derek Turner , Adam A. Goldblum , Robert S. Chao , Daniel Genov
- Applicant: Paul R. Fatheree , S. Derek Turner , Adam A. Goldblum , Robert S. Chao , Daniel Genov
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Roberta P. Saxon
- Main IPC: A61K31/46
- IPC: A61K31/46 ; C07D451/04

Abstract:
The invention provides a crystalline hydrochloride salt of 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-[(R)-2-hydroxy-3-(methanesulfonyl-methyl-amino)propyl]-8-azabicyclo[3.2.1]oct-3-yl}amide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with 5-HT4 receptor activity, and processes useful for preparing such crystalline salt forms.
Public/Granted literature
- US20140256769A1 CRYSTALLINE FORM OF A QUINOLINONE-CARBOXAMIDE COMPOUND Public/Granted day:2014-09-11
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