Invention Grant
US09126997B1 Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma
有权
糖皮质激素受体激动剂与蛋白酶抑制剂联合用于治疗白血病和骨髓瘤的协同作用
- Patent Title: Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma
- Patent Title (中): 糖皮质激素受体激动剂与蛋白酶抑制剂联合用于治疗白血病和骨髓瘤的协同作用
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Application No.: US13226865Application Date: 2011-09-07
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Publication No.: US09126997B1Publication Date: 2015-09-08
- Inventor: Irina Budunova , Alexander Yemelyanov
- Applicant: Irina Budunova , Alexander Yemelyanov
- Applicant Address: US IL Evanston
- Assignee: Northwestern University
- Current Assignee: Northwestern University
- Current Assignee Address: US IL Evanston
- Agency: Andrus Intellectual Property Law, LLP
- Main IPC: C07D471/02
- IPC: C07D471/02 ; C07D271/00 ; A01N43/42
Abstract:
Disclosed are methods and pharmaceutical compositions for treating diseases, disorders, and conditions associated with glucocorticoid receptor (GR) expression and activity. The disclosed methods typically include administering to a patient in need thereof a proteasome inhibitor and administering to the patient in need thereof a glucocorticoid receptor (GR) agonist, either before, concurrently with, or after the proteasome inhibitor is administered.
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