Invention Grant
US09127010B2 Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid
有权
制备13-环己基-3-甲氧基-6- [甲基 - （2- {2- [甲基 - （氨磺酰基） - 氨基] - 乙氧基} - 乙基） - 氨基甲酰基] -7H-吲哚并[2,1-a ] - [2] - 苯并氮杂-10-羧酸
![Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid](/docs/US/2015-09-08/US09127010B2/abs.jpg.600x600.jpg)
- Patent Title: Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid
- Patent Title (中): 制备13-环己基-3-甲氧基-6- [甲基 - （2- {2- [甲基 - （氨磺酰基） - 氨基] - 乙氧基} - 乙基） - 氨基甲酰基] -7H-吲哚并[2,1-a ] - [2] - 苯并氮杂-10-羧酸
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Application No.: US13805607Application Date: 2011-06-24
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Publication No.: US09127010B2Publication Date: 2015-09-08
- Inventor: Tom Cornelis Hortense Govaerts , Jean-Pierre-Andre Marc Bongartz , Patrick Hubert J. Nieste
- Applicant: Tom Cornelis Hortense Govaerts , Jean-Pierre-Andre Marc Bongartz , Patrick Hubert J. Nieste
- Applicant Address: IE Little Island, Co. Cork
- Assignee: Janssen Sciences Ireland UC
- Current Assignee: Janssen Sciences Ireland UC
- Current Assignee Address: IE Little Island, Co. Cork
- Agent Andrea Jo Kamage
- Priority: EP10167221 20100624
- International Application: PCT/EP2011/060606 WO 20110624
- International Announcement: WO2011/161232 WO 20111229
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D223/14 ; C07C307/06
![Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid](/abs-image/US/2015/09/08/US09127010B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to an improved method for the preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid. The present invention also relates to a new compound, namely tert-butyl (methyl-{2-[2-(methylamino)-ethoxy]-ethyl}-sulphamoyl)-carbamate, used in this improved method.
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