Invention Grant
US09127014B2 Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
有权
用于制备N-烯丙基化合物的过渡金属催化方法及其用途
- Patent Title: Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
- Patent Title (中): 用于制备N-烯丙基化合物的过渡金属催化方法及其用途
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Application No.: US13711520Application Date: 2012-12-11
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Publication No.: US09127014B2Publication Date: 2015-09-08
- Inventor: Joshua Robert Giguere , Keith Edward McCarthy , Helge Alfred Reisch , Sergio Sandoval , Jake Larry Stymiest
- Applicant: Rhodes Technologies
- Applicant Address: US RI Coventry
- Assignee: Rhodes Technologies
- Current Assignee: Rhodes Technologies
- Current Assignee Address: US RI Coventry
- Agency: Dechert LLP
- Main IPC: C07D471/00
- IPC: C07D471/00 ; C07D489/08 ; C07C209/00 ; C07C269/04 ; C07D265/30 ; C07C209/44
Abstract:
The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.
Public/Granted literature
- US20130102780A1 TRANSITION METAL-CATALYZED PROCESSES FOR THE PREPARATION OF N-ALLYL COMPOUNDS AND USE THEREOF Public/Granted day:2013-04-25
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