Invention Grant
- Patent Title: Process for preparation of substantially pure fosamprenavir calcium and its intermediates
- Patent Title (中): 制备基本纯净的福沙那韦钙及其中间体的方法
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Application No.: US14285810Application Date: 2014-05-23
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Publication No.: US09127029B2Publication Date: 2015-09-08
- Inventor: Surinder Kumar Arora , Samir Shanteshwar Shabade , Gaurav Kumar , Purna Chandra Ray , Girij Pal Singh
- Applicant: LUPIN LIMITED
- Applicant Address: IN
- Assignee: LUPIN LIMITED
- Current Assignee: LUPIN LIMITED
- Current Assignee Address: IN
- Agency: Cantor Colburn LLP
- Priority: IN1006/KOL/2010 20100910
- Main IPC: C07D307/20
- IPC: C07D307/20 ; C07F9/655 ; C07D405/12 ; G01N30/16
Abstract:
The present invention relates to fosamprenavir calcium (Ia) substantially free of isomer impurity, (3R) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propyl carbamate (Ib), and its process for preparation thereof. The present invention also provides fosamprenavir calcium intermediate, (S)-3-tetrahydrofuranyl-N-succinimidyl carbonate (IIa) substantially free of (R)-3-tetrahydrofuranylsuccinimidyl carbonate (IIb) and its process for preparation thereof.
Public/Granted literature
- US20140256959A1 PROCESS FOR PREPARATION OF SUBSTANTIALLY PURE FOSAMPRENAVIR CALCIUM AND ITS INTERMEDIATES Public/Granted day:2014-09-11
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