Invention Grant
- Patent Title: Enhanced purification of antibodies and antibody fragments by apatite chromatography
- Patent Title (中): 通过磷灰石色谱法增强抗体和抗体片段的纯化
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Application No.: US13310576Application Date: 2011-12-02
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Publication No.: US09127042B2Publication Date: 2015-09-08
- Inventor: Peter S. Gagnon
- Applicant: Peter S. Gagnon
- Applicant Address: US CA Hercules
- Assignee: Bio-Rad Laboratories, Inc.
- Current Assignee: Bio-Rad Laboratories, Inc.
- Current Assignee Address: US CA Hercules
- Agency: Kilpatrick Townsend Stockton LLP
- Main IPC: C07K17/00
- IPC: C07K17/00 ; C07K1/18 ; C07K1/16
Abstract:
Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparation. Integration of such methods into multi-step procedures with other fractionation methods are additionally disclosed.
Public/Granted literature
- US20120077961A1 ENHANCED PURIFICATION OF ANTIBODIES AND ANTIBODY FRAGMENTS BY APATITE CHROMATOGRAPHY Public/Granted day:2012-03-29
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