Invention Grant
- Patent Title: Human cytomegalovirus neutralizing antibodies and use thereof
- Patent Title (中): 人巨细胞病毒中和抗体及其用途
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Application No.: US14138531Application Date: 2013-12-23
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Publication No.: US09127049B2Publication Date: 2015-09-08
- Inventor: Antonio Lanzavecchia , Annalisa MacAgno
- Applicant: Institute for Research in Biomedicine
- Applicant Address: CH Bellinzona
- Assignee: Institute for Research in Biomedicine
- Current Assignee: Institute for Research in Biomedicine
- Current Assignee Address: CH Bellinzona
- Agency: Nelosn Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Jeanne M. DiGiorgio
- Main IPC: C07K16/08
- IPC: C07K16/08 ; A61K38/00 ; C07K14/005 ; A61K39/42 ; A61K39/00
Abstract:
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
Public/Granted literature
- US20140205615A1 HUMAN CYTOMEGALOVIRUS NEUTRALIZING ANTIBODIES AND USE THEREOF Public/Granted day:2014-07-24
Information query
