Invention Grant
US09127056B2 Monospecific and bispecific human monoclonal antibodies targeting insulin-like growth factor II (IGF-II)
有权
针对胰岛素样生长因子II（IGF-II）的单特异性和双特异性人单克隆抗体
- Patent Title: Monospecific and bispecific human monoclonal antibodies targeting insulin-like growth factor II (IGF-II)
- Patent Title (中): 针对胰岛素样生长因子II（IGF-II）的单特异性和双特异性人单克隆抗体
-
Application No.: US14352312Application Date: 2012-10-16
-
Publication No.: US09127056B2Publication Date: 2015-09-08
- Inventor: Dimiter S. Dimitrov , Weizao Chen , Yang Feng
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human
- Applicant Address: US DC Washington
- Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2012/060443 WO 20121016
- International Announcement: WO2013/059206 WO 20130425
- Main IPC: A61K39/395
- IPC: A61K39/395 ; G01N33/53 ; C07K16/22 ; C12N15/13 ; C12N5/10 ; G01N33/574 ; G01N33/74 ; A61K39/00
Abstract:
Monoclonal antibodies (mAbs), antigen binding fragments and engineered antibody domains (eAds) that specifically bind IGF-II are disclosed herein. In some embodiments, these mAbs and eAds are included in a bispecific mAb. In some embodiments, the bispecific antibody specifically binds two different epitopes of IGF-II. Methods of using these mAbs, antigen binding fragments, and eAds, bispecific antibodies, and nucleic acids encoding these mAbs, antigen binding fragments, and eAds, bispecific antibodies are also disclosed.
Public/Granted literature
- US20140271646A1 MONOSPECIFIC AND BISPECIFIC HUMAN MONOCLONAL ANTIBODIES TARGETING INSULIN-LIKE GROWTH FACTOR II (IGF-II) Public/Granted day:2014-09-18
Information query
