Invention Grant
- Patent Title: TFEB variants and uses thereof
- Patent Title (中): TFEB变体及其用途
-
Application No.: US14003505Application Date: 2012-03-07
-
Publication No.: US09127074B2Publication Date: 2015-09-08
- Inventor: Andrea Ballabio , Carmine Settembre , Diego Luis Medina Sanabria
- Applicant: Andrea Ballabio , Carmine Settembre , Diego Luis Medina Sanabria
- Applicant Address: IT Rome
- Assignee: FONDAZIONE TELETHON
- Current Assignee: FONDAZIONE TELETHON
- Current Assignee Address: IT Rome
- Agency: Lucas & Mercanti, LLP
- International Application: PCT/EP2012/053921 WO 20120307
- International Announcement: WO2012/120044 WO 20120913
- Main IPC: C07K14/435
- IPC: C07K14/435 ; A61K38/17 ; A61K31/00 ; C07K14/47 ; A61K31/436 ; A61K31/437 ; A61K31/4375 ; A61K31/4523 ; A61K31/454 ; A61K31/4709 ; A61K31/496 ; A61K31/498 ; A61K31/5377 ; A61K31/5386 ; A61K31/675 ; A61K38/06 ; A61K38/00
Abstract:
The invention refers to TFEB related molecules, as variants, mutants, truncated proteins, chimeras etc. that are constitutively localized in the nucleus of a eukaryote cell. Such molecules have a therapeutic applicability in all of disorders that need of an induction of the cell authophagic/lysosomal system, as lysosomal storage disorders, neurodegenerative diseases, hepatic diseases, muscle diseases and metabolic diseases.
Public/Granted literature
- US20140038897A1 TFEB VARIANTS AND USES THEREOF Public/Granted day:2014-02-06
Information query
