Invention Grant
US09127079B2 Inhibitors of phosphatase and tensin homolog (PTEN) conjugates
有权
磷酸酶和张力蛋白同源物（PTEN）缀合物的抑制剂
- Patent Title: Inhibitors of phosphatase and tensin homolog (PTEN) conjugates
- Patent Title (中): 磷酸酶和张力蛋白同源物（PTEN）缀合物的抑制剂
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Application No.: US13501645Application Date: 2010-10-15
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Publication No.: US09127079B2Publication Date: 2015-09-08
- Inventor: Yu Tian Wang , Shu Zhang , Changiz Taghibiglou
- Applicant: Yu Tian Wang , Shu Zhang , Changiz Taghibiglou
- Applicant Address: CA Vancouver
- Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
- Current Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
- Current Assignee Address: CA Vancouver
- Agency: Bozicevic, Field & Francis LLP
- Agent Carol L. Francis
- International Application: PCT/CA2010/001656 WO 20101015
- International Announcement: WO2011/044701 WO 20110421
- Main IPC: A61K38/10
- IPC: A61K38/10 ; C07K17/02 ; C12N15/12 ; C12N15/63 ; A61K39/395 ; C12N5/02 ; C12N15/85 ; A61P25/16 ; A61P25/28 ; A61P25/00 ; C07K7/08 ; C12N5/10 ; C07K14/47 ; A61K9/00 ; A61K47/48 ; A61K38/00
Abstract:
Described herein are isolated polypeptides having phosphatase and tensin homolog (PTEN) inhibitory activity, vectors and cells for the expression thereof and methods for their use in treating diseases associated with cytotoxic stress, such as spinal cord injury, stroke, traumatic brain injury, multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, and Huntington's disease.
Public/Granted literature
- US20120269829A1 Inhibitors of Phosphatase and Tensin Homolog (PTEN) Compositions, Uses and Methods Public/Granted day:2012-10-25
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