Invention Grant
US09127081B2 Tumor targeted TNF-related apoptosis inducing ligand fusion polypeptide and nucleic acids encoding the same
有权
肿瘤靶向肿瘤坏死因子相关凋亡诱导配体融合多肽和核酸编码相同
- Patent Title: Tumor targeted TNF-related apoptosis inducing ligand fusion polypeptide and nucleic acids encoding the same
- Patent Title (中): 肿瘤靶向肿瘤坏死因子相关凋亡诱导配体融合多肽和核酸编码相同
-
Application No.: US13892238Application Date: 2013-05-10
-
Publication No.: US09127081B2Publication Date: 2015-09-08
- Inventor: Dirk Spitzer , William G Hawkins
- Applicant: Washington University
- Applicant Address: US MO Saint Louis
- Assignee: Washington University
- Current Assignee: Washington University
- Current Assignee Address: US MO Saint Louis
- Agency: Zackson Law LLC
- Agent Saul L. Zackson
- Main IPC: C07K14/435
- IPC: C07K14/435 ; C07K14/52 ; C07K14/525 ; C07K14/705 ; A61K38/16 ; A61K38/17 ; A61P35/00 ; C12N15/09 ; C12N15/11 ; C12N15/62 ; C12N15/63 ; C07K14/47 ; A61K38/19 ; C12N15/70 ; C12N15/74 ; C12N15/79
Abstract:
Fusion polypeptides comprising a TRAIL trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds MUC16, which is prevalent on some tumor cells such as pancreatic and ovarian tumor cells. A sequence that binds MUC 16 can be mesothelin or a MUC16-binding fragment thereof, such as amino acids 1-64 of mesothelin. A fusion polypeptide of the present teachings can induce apoptosis in a target cell such as a MUC16-expressing cancer cell. Also disclosed are nucleic acids encoding the fusion polypeptides, and methods of use of the fusion polypeptides and nucleic acids.
Public/Granted literature
- US20130302270A1 TUMOR TARGETED TNF-RELATED APOPTOSIS INDUCING LIGAND FUSION POLYPEPTIDE, METHODS AND USES THEREFOR Public/Granted day:2013-11-14
Information query
