Invention Grant
US09127087B2 High affinity recombinant sea lamprey antibodies selected by a Yeast Surface Display platform
有权
由酵母表面显示平台选择的高亲和力重组海盏花抗体
- Patent Title: High affinity recombinant sea lamprey antibodies selected by a Yeast Surface Display platform
- Patent Title (中): 由酵母表面显示平台选择的高亲和力重组海盏花抗体
-
Application No.: US13132086Application Date: 2009-11-25
-
Publication No.: US09127087B2Publication Date: 2015-09-08
- Inventor: Zeev Pancer , Roy A. Mariuzza , Satoshi Tasumi , Carlos A. Velikovsky
- Applicant: Zeev Pancer , Roy A. Mariuzza , Satoshi Tasumi , Carlos A. Velikovsky
- Applicant Address: US MD Baltimore
- Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
- Current Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
- Current Assignee Address: US MD Baltimore
- Agency: Moore & Van Allen, PLLC
- Agent Marianne Fuierer
- International Application: PCT/US2009/065852 WO 20091125
- International Announcement: WO2010/065407 WO 20100610
- Main IPC: C40B40/08
- IPC: C40B40/08 ; C07K14/715 ; C12N15/10
Abstract:
The present invention relates to a Yeast Surface Display (YSD) vector for expression of VLR proteins by yeast, wherein the vector includes nucleotide sequences encoding segments of yeast flocculation proteins Flo1p, such as the leader and C-terminal segments, a homologous recombinant cassette and a geneticin/kanamycin resistance gene. The vector can be used for expression of VLR that may be effective in diagnostic applications (e.g., protein chip, immunohistochemistry, flow cytometry), immunoaffinity purification, and for engineering novel fusion proteins.
Public/Granted literature
- US20110230374A1 HIGH AFFINITY RECOMBINANT SEA LAMPREY ANTIBODIES SELECTED BY A YEAST SURFACE DISPLAY PLATFORM Public/Granted day:2011-09-22
Information query
