Invention Grant
US09127249B2 Method for preparing metabolites of atorvastatin using bacterial cytochrome P450 and composition therefor
有权
使用细菌细胞色素P450制备阿托伐他汀代谢物的方法及其组成
- Patent Title: Method for preparing metabolites of atorvastatin using bacterial cytochrome P450 and composition therefor
- Patent Title (中): 使用细菌细胞色素P450制备阿托伐他汀代谢物的方法及其组成
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Application No.: US13639589Application Date: 2012-09-27
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Publication No.: US09127249B2Publication Date: 2015-09-08
- Inventor: Chul-Ho Yun , Dong-Hyun Kim , Ji-Yeon Kang , Sun-Ha Park , Sang-Hoon Ryu
- Applicant: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
- Applicant Address: KR
- Assignee: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
- Current Assignee: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
- Current Assignee Address: KR
- Agency: Cantor Colburn LLP
- Priority: KR10-2011-0118814 20111115; KR10-2012-0094935 20120829
- International Application: PCT/KR2012/007779 WO 20120927
- International Announcement: WO2013/073775 WO 20130523
- Main IPC: C12P17/10
- IPC: C12P17/10 ; C12N9/02
Abstract:
Provided is a novel method for preparing metabolites of atorvastatin using bacterial cytochrome P450, and a composition therefor, and more particularly, a composition for preparing 2-hydroxylated product of 4-hydroxylated product from atorvastatin including bacterial cytochrome P 450 BM3 (CYP102A1), CYP102A1 mutants, and chimeras derived from the CYP102A1 mutants, a kit therefor, and a method for preparing thereof.
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