Invention Grant
- Patent Title: Means and methods for influencing the stability of antibody producing cells
- Patent Title (中): 影响抗体产生细胞稳定性的方法和方法
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Application No.: US12086328Application Date: 2006-12-08
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Publication No.: US09127251B2Publication Date: 2015-09-08
- Inventor: Hergen Spits , Ferenc A. Scheeren , Tim Beaumont , Sean A. Diehl
- Applicant: Hergen Spits , Ferenc A. Scheeren , Tim Beaumont , Sean A. Diehl
- Applicant Address: NL Amsterdam NL Amsterdam
- Assignee: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM,AIMM THERAPEUTICS B.V.
- Current Assignee: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM,AIMM THERAPEUTICS B.V.
- Current Assignee Address: NL Amsterdam NL Amsterdam
- Agency: Saul Ewing LLP
- Agent Gianna Julian-Arnold
- Priority: WOPCT/NL2005/000848 20051209; EP06076211 20060612
- International Application: PCT/NL2006/000625 WO 20061208
- International Announcement: WO2007/067046 WO 20070614
- Main IPC: C12N5/0781
- IPC: C12N5/0781 ; C12N15/63 ; C12N15/64 ; C07K16/00
Abstract:
The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
Public/Granted literature
- US20100113745A1 Means and Methods for Influencing the Stability of Antibody Producing Cells Public/Granted day:2010-05-06
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