Invention Grant
- Patent Title: Cell culture medium for ADAMTS protein expression
- Patent Title (中): 用于ADAMTS蛋白表达的细胞培养基
-
Application No.: US14276819Application Date: 2014-05-13
-
Publication No.: US09127265B2Publication Date: 2015-09-08
- Inventor: Leopold Grillberger , Alexandra Spenger , Meinhard Hasslacher , Rana Grillberger , Manfred Reiter
- Applicant: Baxter International Inc. , Baxter Healthcare SA
- Applicant Address: US IL Bannockburn CH Glattpark (Opfikon)
- Assignee: Baxalta Incorporated,Baxalta GmbH
- Current Assignee: Baxalta Incorporated,Baxalta GmbH
- Current Assignee Address: US IL Bannockburn CH Glattpark (Opfikon)
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: C12N9/64
- IPC: C12N9/64 ; C12P21/06 ; C12N9/50 ; C12N15/00
Abstract:
The present invention provides culture mediums that are useful for the expression of ADAMTS proteins, such as ADAMTS13. Methods for the expression and purification of ADAMTS proteins are also provided. In some embodiments, the mediums and methods of the invention are useful for the expression of ADAMTS proteins having high specific activities. Also provided are ADAMTS, e.g., ADAMTS13, protein compositions with high specific activities, which are expressed and purified according to the methods provided herein.
Public/Granted literature
- US20140329294A1 CELL CULTURE MEDIUM FOR ADAMTS PROTEIN EXPRESSION Public/Granted day:2014-11-06
Information query
IPC分类:
