Invention Grant
- Patent Title: Oligomeric compounds and compositions for the use in modulation of target nucleic acids
- Patent Title (中): 用于调节靶核酸的低聚化合物和组合物
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Application No.: US13353114Application Date: 2012-01-18
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Publication No.: US09127272B2Publication Date: 2015-09-08
- Inventor: Christine Esau , Eric E. Swayze , Balkrishen Bhat , Garth A. Kinberger
- Applicant: Christine Esau , Eric E. Swayze , Balkrishen Bhat , Garth A. Kinberger
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Isis Pharmaceuticals, Inc. Patent Dept. McNeill Baur PLLC
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C12N15/11
Abstract:
Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA activing in a cell.
Public/Granted literature
- US20120115228A1 OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR THE USE IN MODULATION OF MICRORNAS Public/Granted day:2012-05-10
Information query
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