- Patent Title: Non-human animals having a humanized signal-regulatory protein gene
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Application No.: US14516606Application Date: 2014-10-17
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Publication No.: US09127292B2Publication Date: 2015-09-08
- Inventor: Andrew J. Murphy , O. Gavin Thurston , Bindu Varghese , Cagan Gurer
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee Address: US NY Tarrytown
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Agent Neil Miyamoto
- Main IPC: A01K67/027
- IPC: A01K67/027 ; C12N5/10 ; C12N15/85 ; A61K49/00 ; C12N15/89 ; G01N33/50 ; C12N9/16 ; C07K14/705 ; C12N15/90
Abstract:
Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.
Public/Granted literature
- US20150089679A1 NON-HUMAN ANIMALS HAVING A HUMANIZED SIGNAL-REGULATORY PROTEIN GENE Public/Granted day:2015-03-26
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