A vacuum pumping arrangement for evacuating an enclosure is provided. The arrangement comprises a turbomolecular vacuum pump having an inlet which is connectable using fixing members to an outlet of an enclosure to be evacuated. Each of the fixing members passes through a first aperture in the inlet and through a second aperture in the outlet. An elongate, circumferentially extending cavity is provided extending from or adjacent to one of these apertures to accommodate a crushable insert. Energy transmitted to the fixing members by the turbomolecular vacuum pump during a failure thereof is thus absorbed by the deformation of the inserts. By absorbing a proportion of the energy in this way separation of the inlet from the outlet is thus inhibited.