Some embodiments concern a method of isolating low amplitude signals in one or more electrical signals. The method can include: using a data acquisition device to acquire one or more electrical signals; using a first processor to compute one or more first parameters related to the one or more electrical signals; using the first processor to determine one or more first portions of the one or more electrical signal that comprise one or more transient signals; using the first processor to selectively mask the one or more first portions of the one or more electrical signals to create one or more output signals; and adjusting a gain of the data acquisition device based upon one or more second parameters of the one or more output signals. Other embodiments are disclosed.