A POP noise suppression circuit includes a power source terminal, a clock signal input terminal, a charge unit, a discharge unit, a common-mode voltage judging and switching control unit, a charge and discharge capacitor, and a ground terminal. The charge unit includes a first clock generation circuit for generating a first pair of non-overlapped clock signal, and a first equivalent resistor. The discharge unit includes a second clock generation circuit for generating a second pair of non overlapped clock signals, and a second equivalent resistor. The charge unit generates a charge voltage changing slowly to the charge and discharge capacitor. The discharge unit generates a discharge voltage changing slowly to the charge and discharge capacitor. A POP noise suppression system is further provided.