A method for mechanochemical treatment of solid wastes containing perfluorinated or polyfluorinated compounds is provided. It belongs to the field of environment-polluting wastes treatment, and comprises the following steps: mixing the solid waste containing perfluorinated or polyfluorinated compounds with the defluorination reagent under normal temperature and pressure conditions, putting the mixture into a planetary high-energy ball milling reactor; adopting the mechanochemical reaction to realize high-effective degradation and defluorination of perfluorinated or polyfluorinated compounds. When being adopted to degrade perfluorinated or polyfluorinated compounds, this method enjoys such advantages as simple treatment procedure, mild reaction conditions (conducted under normal temperature and pressure conditions), lower energy consumption and operating cost, complete degradation and defluorination of the target pollutants, completely inorganic and harmless end products and free of liquid or gas byproducts.