Invention Grant
US09133519B2 Compositions and methods for diagnosis of genetic susceptibility, resistance, or tolerance to infection by mycobacteria and bovine paratuberculosis using promoter variants of EDN2
有权
使用EDN2的启动子变体诊断分枝杆菌和牛副结核病感染的遗传易感性，耐药性或耐受性的组合物和方法
- Patent Title: Compositions and methods for diagnosis of genetic susceptibility, resistance, or tolerance to infection by mycobacteria and bovine paratuberculosis using promoter variants of EDN2
- Patent Title (中): 使用EDN2的启动子变体诊断分枝杆菌和牛副结核病感染的遗传易感性，耐药性或耐受性的组合物和方法
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Application No.: US13838877Application Date: 2013-03-15
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Publication No.: US09133519B2Publication Date: 2015-09-15
- Inventor: Holly L. Neibergs , Ricardo Zanella , Jeremy F. Taylor , Zeping Wang , Erik Scraggs , Stephen N. White , Robert Schnabel , Curtis P. Van Tassell
- Applicant: Washington State University
- Applicant Address: US WA Pullman US MO Columbia US DC Washington
- Assignee: WASHINGTON STATE UNIVERSITY,UNIVERSITY OF MISSOURI,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
- Current Assignee: WASHINGTON STATE UNIVERSITY,UNIVERSITY OF MISSOURI,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
- Current Assignee Address: US WA Pullman US MO Columbia US DC Washington
- Agency: Whitham, Curtis, Christofferson & Cook, P.C.
- Main IPC: A01K67/00
- IPC: A01K67/00 ; C12N15/00 ; C12Q1/68
Abstract:
Provided are methods for determining susceptibility, resistance or tolerance to Mycobacterium avium subspecies paratuberculosis (Map) infection, comprising: determining, using a biological sample from a mammalian subject, a presence or absence of at least one EDN2 gene mutation, or the genotype of at least one EDN2 gene single nucleotide polymorphism (SNP) selected from the SNP group consisting of SNP105 (nucleotide position 105,288,174 on BTA3 (UMD 3.1)), SNP208 (nucleotide position 105,298,664 on BTA3 (UMD 3.1)), and SNP272 (nucleotide position 105,305,070 by on BTA3 (UMD 3.1)), that segregates with resistance and/or tolerance to Map tissue infection; and determining, based thereon, at least one of susceptibility, resistance or tolerance of the mammalian subject to Map infection. Additionally provided are mammals (e.g., bovine) derived culling, selecting, or selective breeding, based on disclosed methods, and methods for procuring mammals. Preferably, the mammals carry non-susceptible alleles of SNP105 (G), SNP208 (G), and SNP272 (G).
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