Disclosed herein are an analog compensation circuit and a method for tuning an analog compensator in full-duplex transmission systems. An embodiment analog compensation circuit includes a secondary receiver configured to receive and convert a sampled self-interference signal to a baseband self-interference signal. A tuner is coupled to the secondary receiver and configured to receive a baseband transmit signal and the baseband self-interference signal, and to compute complex gains according to the baseband transmit signal and the baseband self-interference signal. An analog compensator is coupled to the tuner and has multiple branches. The analog compensator is configured to receive the complex gains and use them to adjust respective attenuators and phase shifters of the branches. The analog compensator is further configured to process a sample of a transmit signal using the branches, the transmit signal being up-converted from a new baseband transmit signal.